Table 3.
The significantly differentially expressed proteins in untreated asthmatics compared to healthy controls
| Swiss Prot Acc. No. | Symbol | Entrez Gene Name | Fold Change | Location | Protein Class |
|---|---|---|---|---|---|
| P08758 | ANXA5 | annexin A5 | -1.98 | Plasma membrane | transfer/carrier protein |
| Q07507 | DPT | dermatopontin | -2.15 | Extracellular space | extracellular matrix binding protein |
| Q96KK5 | HIST1H2AH | histone cluster 1, H2ah | -2.85 | Nucleus | histone |
| P02545 | LMNA | lamin A/C | -1.85 | Nucleus | structural protein |
| P62937 | PPIA | peptidylprolyl isomerase A (cyclophilin A) | -1.64 | Cytoplasm | isomerase |
| P18124 | RPL7 | ribosomal protein L7 | -1.82 | Cytoplasm | ribosomal protein |
| P62917 | RPL8 | ribosomal protein L8 | -1.76 | Cytoplasm | ribosomal protein |
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All listed proteins showed a statistically significant difference (p value < 0.05) between the groups using a Student's t-test. The fold change for each protein is calculated by dividing the average ratio of the untreated asthmatics with the average ratio of the healthy controls. The negative fold change indicates down regulation of protein expression in asthmatic patients. The cell location of the protein is annotated by IPA. The protein class is determined using the PANTHER Classification System.