Table 4.

Significantly modified proteins in post treated placebo versus pre treated placebo asthmatic patients

Swiss Prot Acc. No.	Symbol	Entrez Gene Name	Fold Change	Location	Protein Class
P60709	ACTB	actin, beta	-1.66	Cytoplasm	actin and actin related protein
P05783	KRT18	keratin 18	1.31	Cytoplasm	structural protein
P01009	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	2.34	Extracellular space	serine protease inhibitor

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All listed proteins showed a statistically significant difference (p value < 0.05) between the groups using a Student's t-test. The fold change for each protein is calculated by dividing the average ratio of the placebo post treated biopsy with the average ratio of the paired pre placebo biopsy. The negative fold change indicates down regulation of protein expression by placebo, while the positive fold change indicates up regulation by placebo. The cell location of the protein is annotated by IPA. The protein class is determined using the PANTHER Classification System.