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Pathophysiology of chronic constipation
| Primary causes | Secondary causes |
|---|---|
| Normal transit (most common) | Medications |
| Slow transit | Obstruction (eg, cancer, stricture) |
| Evacuation disorder | Metabolic (eg, hypothyroid, hypercalcemia) |
| Neurological (eg, parkinsonism, multiple sclerosis) | |
| Systemic (eg, scleroderma, amyloidosis) | |
| Psychiatric (eg, depression, eating disorders) |
