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. 1999 Jul 26;146(2):517–529. doi: 10.1083/jcb.146.2.517

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Immunolocalization of MMP-9 in cryosections of human bronchial tissue samples and cultures of repairing HBEC. The localization of MMP-9 was studied by immunofluorescence, using the GE 209 mAb. (A and B) A normal bronchial epithelium in which MMP-9 was seen in sporadic inflammatory cells (B, arrows). (C and D) In a remodeled human bronchial epithelium, MMP-9 was recognized in elongated cells (D, arrows) spread on the basement membrane. (E and F) In a normal human epithelium, which had been locally wounded and maintained in culture for 1 d, MMP-9 was observed only in flat epithelial cells (F, arrows) near the edge of the wound (E, arrow). (G and H) In a confluent primary culture of HBEC, which had been locally injured, MMP-9 was identified 1 d after injury only in cells located at the edge of the wound. In these cells, MMP-9 was predominantly located around the nucleus but had also accumulated at the extremity of cellular protrusions in the direction of cell migration (H, arrows). Bars, 100 μm.