Skip to main content
. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2011 Sep 29;19(22):6743–6749. doi: 10.1016/j.bmc.2011.09.049

Figure 4. Aurora A Assays of Selected Peptides Show Low Micromolar Inhibition Constants.

Figure 4

(A) The optimized selection conditions yielded several convergent sequences with no dominating sequence. (B) Two peptides from the selection have potent IC50’s of 10.5 μM for (CTRPWWLC)G and 6.2 μM for (CPRFLPWC)G at 0.5 nM AUR2. (C) Two selected peptides that were synthesized and evaluated in AUR2 kinase assays.