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. Author manuscript; available in PMC: 2011 Nov 2.
Published in final edited form as: Exp Physiol. 2008 Oct 17;94(1):31–37. doi: 10.1113/expphysiol.2008.043638

Figure 3. Mechanism of NPY’s effect on the adrenergic component of sympathetic neurogenic contraction.

Figure 3

Adrenergic contractions were induced with PE (2μM) in the absence (Fig. 3A) and presence (Fig. 3B) of 10nM NPY. The top most trace shows force, the bottom traces are calcium signals within three different arterial smooth muscle cells using confocal wire myography. 10nM NPY increases the frequency of asynchronous calcium waves induced by 2μM PE from 1.38±0.28 to 3.95±0.54 waves/cell/min (120 cells, 3 arteries) and increased the force 3-fold, n=3.