Skip to main content
. Author manuscript; available in PMC: 2011 Nov 2.
Published in final edited form as: Nature. 2010 Nov 11;468(7321):232–243. doi: 10.1038/nature09613

Figure 4. Nitric oxide inhibits the production of key arachidonic acid-derived messengers.

Figure 4

NO inhibits (dashed lines) the production of both the vasoconstricting 20-HETE and the vasodilating EETs36,69. NO also weakly stimulates COX1 and inhibits COX2 (not shown)65. Endothelial nitric oxide synthase (eNOS) can be activated by flow-induced shear stress or by acetylcholine (ACh). Other abbreviations as in earlier figures.