Table 1. Comparison of primer locations and association between APC promoter methylation and HCC in previously published articles.
| Study[reference] | Primer location | Assayformat | Percent of tissue methylated (sample size) | |
| Non-HCC | HCC | |||
| 1 [4] | Sense | MSP | 0 (20) | 81.7 (60) |
| 2 [32] | Sense | MSP | 14.3 (14) | 53 (51) |
| 3 [6] | Sense | MSP | NA (95% specificity, n = 20 for HCC and non-HCC tissue) | |
| 4 [34] | Antisense | MethyLight-Taqman | 81 (19) | 100 (19) |
| 5 [35] | Antisense | MethyLight-Taqman | 48 (25) | 78 (40) |
| 6 [33] | Antisense | Quantitative MSP | 100 (16) | 100 (34) |
Note: NA, not applicable.