Figure 5. Tregs inhibit NKT cell mediated hepatitis.

Tregs (CD4⁺ CD25⁺) and Teff (CD4⁺CD25⁻) were isolated from the spleen of either wt or CD1dko C57BL6 mice and adoptively transferred (1.5×10⁶ Tregs for each recipient mouse) into wild-type C57BL6 mice. 24 hour after adoptive transfer, the recipient mice were injected with α-Galcer to induce hepatits. Liver tissue and blood were collected 3 days later. A) Representative H&E stain of liver histology. B) Mean (±SD) serum ALT levels of four experiments, *p<0.01 vs other groups treated with α-Galcer.