Table 1.
Average nuclear morphology measurements at each of the 100-μm epithelial depth segments for nondysplastic and dysplastic biopsies as measured by a/LCI. Data are given as mean (SD) and statistical significance as indicated with associated p-value. NS indicates that the specified characteristic was unable to differentiate dysplasia at a statistically-significant level (P < 0.05). Single and triple asterisks indicate statistical significance at the P < 0.05 and P < 0.001 level, respectively.
| Nondysplastic (n = 67) | Dysplastic (n = 14) | Statistical significance | |
|---|---|---|---|
| Nuclear diameter (0 to 100 μm) | 9.73 μm (1.43 μm) | 9.52 μm (1.23 μm) | NS (p = 0.29) |
| Nuclear density (0 to 100 μm) | 1.042 (0.0036) | 1.044 (0.0058) | NS (p = 0.64) |
| Nuclear diameter (100 to 200 μm) | 10.52 μm (1.36 μm) | 9.64 μm (1.61 μm) | * (p = 0.036) |
| Nuclear density (100 to 200 μm) | 1.043 (0.0036) | 1.044 (0.0045) | NS (p = 0.36) |
| Nuclear diameter (200 to 300 μm) | 9.29 μm (1.28 μm) | 11.58 (1.36 μm) | *** p < 0.0001 |
| Nuclear density (200 to 300 μm) | 1.045 (0.0040) | 1.041 (0.0028) | ***p < 0.0001 |