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. 2011 Oct 4;16(10):106006. doi: 10.1117/1.3638180

Figure 8.

Figure 8

Exposure and displacement of juxtaparanodal Kv1.2 channels. Red: myelin imaged by CARS; green: immunolabeled Kv1.2 channels imaged by TPEF. (a) Mosaic image showing a large view of Kv1.2 labeling and myelin in a lumbar spinal slice at the peak acute EAE. (b) A typical image of paired Kv1.2 channels in the naive white matter that are located at the juxtaparanodes and concealed beneath the compact myelin. (c) NAWM at the peak acute EAE showing paired Kv1.2 labeling (stars) under the myelin cover. (d, e) Exposed Kv1.2 channels [arrows in (d)] and displacement of Kv1.2 channels into the paranodes and nodes at the border of demyelinating lesions. In the lesions where myelin debris was present, no paired Kv1.2 channels were observed. (f) Exposure and displacement of Kv1.2 channels in the white matter of EAE onset. Bar = 50 μm in (a); bar = 5 μm in (b, e, f); bar = 10 μm in (c, d).