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. 2011 Nov 2;6(11):e27106. doi: 10.1371/journal.pone.0027106

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Kawai, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Wounded mice received an injection of either calcium chloride, calcium-based nanoparticles (CNPs) or saline via the tail vein. The rate of wound healing was assessed after treatment in each group. Both calcium chloride and CNP-treatment accelerated wound healing relative to controls. CNP-treatment significantly decreased wound area compared to calcium chloride treatment by day 2 (N = 4 per group). P-values were calculated using the Dunnett's test. The data is expressed as the mean ± SD. (B) Serum calcium levels of mice were measured after they received an injection of calcium chloride, calcium-based nanoparticles or saline. Serum calcium levels remained unchanged after CNP injection, but were significantly increased 1 hour after CaCl₂ injection.