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. 2011 Nov 2;6(11):e27106. doi: 10.1371/journal.pone.0027106

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Kawai, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Wounded mice received a topical application of either calcium chloride, calcium-based nanoparticles (CNPs) or saline. Topically applied calcium-based nanoparticles did not enhance wound healing. However, topically applied calcium chloride significantly increased the rate of wound healing relative to controls. P-values were calculated using the Dunnett's test. The data is expressed as the mean ± SD.