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. 2011 Nov 2;6(11):e27106. doi: 10.1371/journal.pone.0027106

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Kawai, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) BrdU incorporation after 12 hrs of growth with calcium-based nanoparticles (CNP) in NIH3T3 fibroblasts. CNP-treatment increased fibroblast proliferation rate, which was dependent on CNP concentration in a dose-dependent manner. (B) Fibroblasts were added to a collagen lattice to form a fibroblast populated lattice complex. The surface area of the FPCL reduced over time depending on CNP concentration. The amount of contractility is inversely proportional to FPCL size. CNP-treatment increased FPCL contraction. P-values were calculated using the Dunnett's test. The data is expressed as the mean ± SD.