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. 2011 Nov 2;6(11):e27165. doi: 10.1371/journal.pone.0027165

Figure 2. MEF2 binding sites are critical for the promoter activity of PRL-3.

Figure 2

(A) The region between −158 and −33 is important for the transcriptional activity of the PRL-3 promoter, as measured by luciferase activity. (B) The effect of site-directed mutations in the MEF2 binding sites, as measured by luciferase activity. All luciferase activity were normalized to β-galactosidase activity and standardized to the normalized activity of pGL3-Basic. Each column represents the mean ± SD of three independent experiments. ** significantly different from the control at P<0.01.