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. 2011 Nov 2;6(11):e27228. doi: 10.1371/journal.pone.0027228

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Chuck et al.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Relative protease activity of 3CL^pro from HCoV-NL63 (circles, group 1), HCoV-OC43 (squares, group 2a), SARS-CoV (diamond, group 2b) and IBV (triples, group 3) against 19×8 of substrate variants were measured by FRET assay. Relative activities that are significantly (p-value<0.001) higher than the rest are represented as filled symbols.