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. 2011 Nov 2;6(11):e27228. doi: 10.1371/journal.pone.0027228

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Chuck et al.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The relative protease activities of 3CL^pro from HCoV-NL63 (shaded, group 1), HCoV-OC43 (white, group 2a), SARS-CoV (black, group 2b) and IBV (grey, group 3), were correlated with structural properties of substituting residue properties, including side chain volume [28], hydrophobicity [29] and α-helix and β-sheet propensities [30]. Correlation coefficients of +/−0.56 and +/−0.44 correspond to p-values of 0.01 and 0.05 respectively.