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. 2011 Nov 2;6(11):e27187. doi: 10.1371/journal.pone.0027187

Figure 5. Systemic ODQ administration improves stepping performance in chronic MPTP-treated mice.

Figure 5

(a) Chronic MPTP treatment significantly reduced the number of TH positive neurons in the SN. The data were collected at four anatomical levels from vehicle or MPTP-treated mice 3 weeks following the last injection (**P<0.005 compared to vehicle). (b) Images of TH immunostaining showing the degree of reduction of TH positive cells in the SN at four anatomical levels (mm from bregma): −3.1 (i, v), −3.3 (ii, vi), −3.5 (iii, vii) and −3.7 (iv, viii). (c) Summary graph depicting the effect of chronic saline (n = 9) or MPTP (20 mg/kg, s.c., n = 13) injections on forelimb stepping performance. A significant decrease in the number of adjusting steps was observed after 6 weeks of MPTP injection (**P<0.005 vs. vehicle, Tukey post-hoc test after significant ANOVA). (d) Time course showing the effect of a single s.c. injection of vehicle and ODQ (5 and 10 mg/kg) on MPTP-induced stepping deficits (n = 5–7 mice per group). A transient improvement in stepping performance was detected 30–90 min after ODQ administration (**P<0.005, compared to measures taken at time 0 or identical time points in vehicle, Tukey post-hoc test after significant two-way ANOVA).