A). Total cellular proteins were prepared using lysis buffer containing 2% SDS, 100 mM DTT, 60 mM Tris (pH 6.8), 10% glycerol and separated on a 10% SDS-polyacrylamide gel, and transferred onto nitrocellulose membrane. Immunoblots were probed with antibodies specific for CD44, BCL2, caspase-3. The blots were then re-probed with β-actin as a loading control. B). Quantification of the results from A using ImageJ, expressed as a ratio of the expression level of target genes against β-actin. The results were calculated as mean ± SD. The statistical differences between the combination treatment vs. control or DHA or VP16 alone were determined using paired student’s t-test and performed using SPSS. ***p<0.001.