Predicted and observed Fst. (A) The predicted and observed Fst values between an admixed Mestizo population and a European founding population are plotted against the European admixture fraction γ in the Mestizo population, estimated by maximum likelihood. The prediction is based on eq. 7, using the European and Native American allele frequencies estimated from Wang et al. (2008) as , respectively, together with the maximum likelihood estimate of γ. The observation is based on Fst estimated from eq. 1, inserting estimated allele frequencies from Wang et al. (2008) on European and Mestizo populations. (B) The observed Fst value is plotted against the predicted Fst value. The identity line is shown in gray. In both panels, each point represents one of the 678 loci used. The correlation coefficient between the predicted and observed Fst values is 0.978.