Fig. 8.

In silico validation of gene expression in the thyroid and lung primordia at E14.5 by semiquantification of transcript levels in publicly deposited images from automated in situ hybridization of mouse embryo sections (GenePaint database (Max Planck Institute, Hannover) (Visel et al., 2004)). Genes from the TBEG and LBEG sets with a relative enrichment > 10 in the primordia were analyzed. The graph shows the percentage of genes that show a strong expression in the organ buds, defined as a signal in the thyroid (red) or lung (blue) that is either the strongest in the embryo or stronger than that in the liver, heart, brain or mandibular mesenchyme. As a control, the same analysis was performed on 100 randomly selected genes (gray).