Table 5.

Association of CYP2D6 Genotype with odds of Breast Cancer risk

Treatment	Status	EM/EM (baseline)	EM/IM	IM/IM	EM/PM	PM/IM	PM/PM	Missing Genotype data
Tamoxifen	Controls	243	86	8	195	29	32	2
	Cases	129	46	4	97	23	16	3
	Odds Ratio	1	0.994	1.096	0.947	1.461	0.895
	95% CI	-	(0.651–1.518)	(0.309–3.889)	(0.677–1.325)	(0.787–2.711)	(0.462–1.736)
	p-value	-	0.979	0.888	0.75	0.229	0.743
Raloxifene	Controls	226	61	4	175	34	28	3
	Cases	107	47	4	72	22	21	0
	Odds Ratio	1	1.671	2.417	0.87	1.321	1.597
	95% CI	-	(1.052–2.653)	(0.513–11.379)	(0.605–1.25)	(0.747–2.335)	(0.872–2.924)
	p-value	-	0.03	0.264	0.451	0.338	0.129
Total	Controls	469	147	12	370	63	60	5
	Cases	236	93	8	169	45	37	3
	Odds Ratio	1	1.257	1.566	0.916	1.386	1.213
	95% CI	-	(0.922–1.713)	(0.601–4.085)	(0.717–1.171)	(0.914–2.103)	(0.778–1.891)