Table 3.
Association of TP53 mutation status with survival time and incidence of cervical lymph node metastasis in the orthotopic nude mouse model of HNSCC
| Mutation status | No. of mice | No. of deaths | Survival time (days) Mean ± SD |
Hazard ratio for death (95% Cl) | P value from log-rank test (verses wild-type) | No. of mice with and without cervical lymph node metastasis | % of mice with cervical lymph node metastasis | P value from Fisher’s exact test (versus wild-type) | |
|---|---|---|---|---|---|---|---|---|---|
| With | Without | ||||||||
| p53 status | |||||||||
| Wild-type | 49 | 9 | 55.1 ± 10.8 | 1 | 48 | 2 | |||
| Mutant | 421 | 134 | 51.7 ± 13.5 | 0.6069 (0.3595 to 1.025) | 0.062 | 51 | 370 | 12.1 | 0.03 |
| Mutation category | |||||||||
| Classification of Poeta et al. | |||||||||
| Wild-type | 49 | 9 | 55.1 ± 10.8 | 1 | 48 | 2 | |||
| Nondisruptive | 345 | 94 | 52.9 ± 13.0 | 0.6821 (0.3832 to 1.214) | 0.193 | 29 | 316 | 8.4 | 0.152 |
| Disruptive | 76 | 40 | 46.2 ± 14.4 | 0.340 (0.192 to 0.603) | 0.0002 | 22 | 54 | 29 | 0.0001 |
| new classification | |||||||||
| Wild-type | 49 | 9 | 55.1 ± 10.8 | 1 | 48 | 2 | |||
| Null | 138 | 40 | 52.2 ± 13.9 | 0.6275 (0.3333 to 1.181) | 0.149 | 12 | 126 | 8.7 | 0.189 |
| Overexpressed | 283 | 94 | 50.8 ± 13.6 | 0.583 (0.342 to 0.993) | 0.047 | 39 | 244 | 13.8 | 0.016 |
| Nondisruptive | 227 | 64 | 52.1 ± 13.2 | 0.660 (0.365 to 1.194) | 0.169 | 23 | 204 | 10.1 | 0.091 |
| Disruptive | 56 | 30 | 46.1 ± 14.3 | 0.306 (0.161 to 0.580) | 0.0003 | 16 | 40 | 28.6 | 0.0001 |
Abbreviation: SD, standard deviation.