Table 1.
Baseline characteristics of patients in the derivation and validation cohorts; patients are free of a diagnosis of gastro-oesophageal cancer at baseline, (Figures are n [%] unless otherwise specified)
| Derivation cohort | Validation cohort | |
|---|---|---|
| Characteristic | (n = 2 355 719) | (n = 1 238 971) |
| Female | 1 174 921 (49.9) | 617 493 (49.8) |
| Male | 1 180 798(50.1) | 621 478(50.2) |
| Mean age (SD), years | 50.1 (15.0) | 50.1 (15.0) |
| Mean Townsend score (SD) | -0.3 (3.4) | -0.2(3.6) |
| BMI recorded priorto study entry | 1 869 779 (79.4) | 1 005 846(81.2) |
| Mean BMI (SD), kg/m2 | 26.4(4.6) | 26.4(4.7) |
| Smoking status | ||
| Non-smoker | 1 194 692 (50.7) | 624 788(50.4) |
| Ex-smoker | 427 246(18.1) | 229 516(18.5) |
| Current smoker, amount not recorded | 71 416(3.0) | 39 231 (3.2) |
| Light smoker (<10/day) | 148 063(6.3) | 79 844 (6.4) |
| Moderate smoker (10-19/day) | 179 931 (7.6) | 95 754(7.7) |
| Heavy smoker (≥20/day) | 133 980 (5.7) | 73 554(5.9) |
| Smoking status not recorded | 200 391 (8.5) | 96 284 (7.8) |
| Alcohol status | ||
| None | 511 397 (21.7) | 275 795(22.3) |
| Trivial (<1 unit/day) | 657 782 (27.9) | 356 394(28.8) |
| Light (1-2 units/day) | 493 275 (20.9) | 257 800 (20.8) |
| Moderate or heavy (≥3 units/day) | 176 350 (7.5) | 93 310 (7.5) |
| Alcohol status not recorded | 516 915 (21.9) | 255 672 (20.6) |
| Medical history | ||
| Family history of gastrointestinal cancer | 29 636(1.3) | 17 742(1.4) |
| Prior cancer apart from gastro-oesophageal cancer | 53 971 (2.3) | 28 520(2.3) |
| Current symptoms and symptoms in the preceding year | ||
| Current dysphagia | 15 021 (0.6) | 8165 (0.7) |
| Current haematemesis | 12 952 (0.5) | 7119 (0.6) |
| Current abdominal pain | 225 543 (9.6) | 126 161 (10.2) |
| Current appetite loss | 9978 (0.4) | 6133(0.5) |
| Current weight loss | 9998 (0.4) | 5377 (0.4) |
| Tiredness in last year | 25 200 (1.1) | 14 119 (1.1) |
| Haemoglobin recorded in the last year | 22 576 (1.0) | 12 638(1.0) |
| Haemoglobin <11 g/dl in the last year | 406 410 (17.3) | 218 862 (17.7) |
BMI = bodymass index. SD = standard deviation. Figures in the tables are counts (%) unless otherwise specified.