Figure 2.

Human RIG-I^SF2 solution structure. (A) Experimental X-ray scattering intensities of human RIG-I^SF2 (blue dots) and calculated scattering intensities from the crystal structure of mouse RIG-I^SF2 (black line), indicating that the mouse RIG-I^SF2 crystal structure is a good model for the human RIG-I^SF2 solution structure. (B) Averaged small-angle X-ray scattering envelope obtained from 16 independent ab initio models from human RIG-I^SF2 (grey) shows the three-lobed ‘C’ shape, with the model of the crystal structure of mouse RIG-I^SF2. Figures and docking were generated using the Situs package (Wriggers, 2010) and University of California, San Francisco Chimera (Pettersen et al, 2004). RIG-I, retinoic acid inducible gene I.