Fig. 2.

Progranulin and TDP-43 immunoreactivity in human and rodent brains. Progranulin immunoreactivity in a human (a) and a rodent brain (b) showing that although GRN immunoreactivity is strongly present in microglia (arrows in b), neuronal punctate immunoreactivity is also characteristically present in the cortical brain regions. c TDP-43 reactivity in a FTLD patient showing that TDP-43 reactivity is not only absent in a cell with TDP-43 inclusion (“nuclear clearing”) but is also absent to weak in some cells without inclusions. d Similar observations are also made in rodent brain showing highly variable TDP-43 expression in the nucleus. Scale bar, 20 μm