Fig. 1.

Gene structure of the TMEM106B gene. The relative position of the three replicated SNPs from the FTLD-TDP GWA study is indicated. Mutation analysis by exonic sequencing in 288 Flanders–Belgian FTLD patients identified two coding variants, one rare missense variant S134N in exon 5 and one common missense variant T185S (rs3173615) in exon 6. T185S was found in high linkage disequilibrium with rs1990622 in the Flanders–Belgian population (r ² = 98)