Table 2.
Genotypic association of TMEM106B in the Flanders–Belgian clinical FTLD cohort
| dbSNP ID | Genotype | Genotype frequency | OR [95% CI] | P value | |
|---|---|---|---|---|---|
| Patients (n = 288) | Controls (n = 595) | ||||
| rs1020004 | TT | 0.52 | 0.48 | / | / |
| CT | 0.41 | 0.42 | 0.91 [0.68–1.23] | 0.536 | |
| CC | 0.06 | 0.10 | 0.51 [0.29–0.91] | 0.023 | |
| rs6966915 | CC | 0.42 | 0.34 | / | / |
| CT | 0.45 | 0.49 | 0.74 [0.54–1.01] | 0.055 | |
| TT | 0.13 | 0.17 | 0.60 [0.39–0.94] | 0.025 | |
| rs1990622 | TT | 0.42 | 0.33 | / | / |
| CT | 0.45 | 0.49 | 0.72 [0.53–0.98] | 0.036 | |
| CC | 0.13 | 0.18 | 0.59 [0.38–0.91] | 0.019 | |
P values and odds ratios (OR) with associated 95% confidence intervals (CI) were calculated under an additive model using logistic regression adjusted for age and gender using the common genotype as reference