Figure 1.

Protein sequence comparisons between γ- and δ-sarcoglycans. (A) The alignment of γ- and δ-sarcoglycans with a predicted open reading frame from the Caenorhabditis elegans cosmid F07H5.2 using the GRAIL exon prediction program. The protein sequence from the intracellular tails of γ- and δ-sarcoglycans (consisting of the first 39 and 41 amino acids, respectively) and a predicted open reading frame from a C. elegans were aligned using the MacVector™ software. (B) Protein sequence comparison of the three filamin family members. The carboxy terminus of the filamins were aligned using MacVector™ software. The two hinge regions are underlined. The peptide sequence used to raise the FLN2-A2 antibody is boxed.