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. 2000 Jan 10;148(1):101–114. doi: 10.1083/jcb.148.1.101

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Electron micrographs of IFMs derived from wild-type and kettin mutant pharate adults (late pupae). A, C, and E are longitudinal sections, whereas B, D, and F are transverse sections. A and B, wild type; C and D, ket14/+; and E and F, ket⁵/ket⁵. IFM contraction is considered to be initiated after eclosion. ket14/+ IFMs are virtually normal in appearance (compare C and D with A and B), but destroyed after eclosion (Fig. 7 I), indicating that kettin is essential for the maintenance of IFMs. On the other hand, ket⁵/ket⁵ IFMs possessed morphological defects before eclosion; myofilaments were normally packed to generate the typical hexagonal lattice in the center, but the lattice structure appeared loose in the periphery near Z-discs (E and F, arrowheads); as shown by the arrows in E, M-lines are normally formed. These findings may suggest that kettin is also involved in normal IFM formation most probably through Z-disc formation. Bar: (A, C, and E) 0.5 μm; (B, D, and F) 0.25 μm.