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. 2011 Nov 2;101(9):2131–2138. doi: 10.1016/j.bpj.2011.09.043

Figure 4.

Figure 4

FAK increases cell stiffness and adhesion strength, and reduces cytoskeletal dynamics. Cell stiffness (magnitude of the shear modulus) (A) and exponent of the creep modulus (B) measured with magnetic tweezer microrheology at different forces. (C) Adhesion strength of fibronectin-coated beads expressed as percentage of detached beads versus pulling force. (D) Cell stiffness (shear modulus) measured with an uncoated AFM-tip. Apparent diffusivity (E) and power-law exponent of the mean-squared displacement (F) of spontaneous movements of FN-coated beads attached to the cell surface. (Bars) Standard error. (Asterisk) Significant (p < 0.05) differences.