Table 1.

Estimated parameter values and the corresponding normalized sensitivity coefficients for the kinetic model of mitochondrial Ca²⁺ uniporter

Parameters(ϕi)	Model 1		Model 2		Model 3		References
	Value	$S_{{\varphi }_i}^E$	Value	$S_{{\varphi }_i}^E$	Value	$S_{{\varphi }_i}^E$
k0 (nmol/mg/s)	1.27 × 10−3	0.0671	1.49 × 10−3	0.2692	1.58 × 10−3	0.3302	(9)
	20.32 × 10−3	0.0671	22.35 × 10−3	0.2692	22.12 × 10−3	0.3302	(11)
	16.51 × 10−3	0.0671	19.37 × 10−3	0.2692	20.54 × 10−3	0.3302	(14)
	27.94 × 10−3	0.0671	30.55 × 10−3	0.2692	29.23 × 10−3	0.3302	(15)
	63.5 × 10−3	0.0671	62.58 × 10−3	0.2692	60.04 × 10−3	0.3302	(16)
K0C (M)	3.965 × 10−6	0.1131	2.786 × 10−6	0.4946	1.955 × 10−6	0.7319	All
K0M (M)	0.655 × 10−3	0.0564	0.542 × 10−3	0.1725	0.403 × 10−3	0.4218	All
γ (Unitless)	3.9	0.1784	5.7	0.1739	9.2	0.1412	All
KPi (M)	0.2 × 10−3	0.0319	0.2 × 10−3	0.1678	0.2 × 10−3	0.2696	All
Eϕ; SEϕ	0.077; 0.447		0.058; 1.278		0.053; 1.895		Eqs. 10 and 11

Rate constant k⁰ is redefined as k⁰ = [T]_tot · k⁰. Note that the apparent values of K⁰_C and K⁰_M calculated using Eq. 9 for different [Pi] matches well with the estimates in Table S1 of Appendix SB in the Supporting Material, obtained without considering the Pi regulation mechanism of K⁰_C and K⁰_M.