Figure 7. Sergeants-and-soldiers chiral amplification kinetics.

Simulated chiral amplification kinetics evolving via the sergeants-and-soldiers principle upon titration of a solution of (R)-1 in heptane (χ=10%) to a solution of (A)-2 in heptane (χ=90%) at a total concentration of 2.1×10⁻⁵ M and a temperature of 337 K. Nine lines from different simulations, using 5,000,000 molecules, are shown. The insets show snapshots of a movie that was constructed from the time-dependent output of such simulations using 10,000 molecules. On mixing of chiral (R)-1 as aggregates (red), monomer dissociation results in incorporation of chiral monomers in achiral P- and M-type stacks (black) eventually leading to a breakdown of the M-type aggregates. Chiral amplification was quantified as (P_tot−M_tot)/(P_tot+M_tot), in which P_tot and M_tot represent the concentration of BTA molecules in P- and M-type aggregates, respectively. The full movies are available in the Supplementary Information.