Table 3.
Over‐represented functional categories of 1077 genes found in any of the five screens
| Rank# | Gene classification cluster | Enrichment score* | No of genes |
|---|---|---|---|
| 1 | Kinase/signaling | 29.52 | 134 |
| 2 | Mitosis/cell cycle | 16.24 | 9 |
| 3 | Translation initiation | 12.69 | 12 |
| 4 | Ribosome | 11.54 | 29 |
| 5 | Phosphoinositide metabolic process | 10.34 | 7 |
| 6 | mRNA processing | 9.66 | 44 |
| 7 | ABC transporter | 9.26 | 5 |
| 8 | Protein transport | 8.6 | 4 |
| 9 | Nucleus | 8.04 | 7 |
| 10 | Regulation of ubiquitin‐protein ligase activity | 8.01 | 23 |
| 11 | PI3 kinase | 5.21 | 4 |
| 12 | Ras small GTPase, Rab type | 5.03 | 10 |
| 13 | Nuclear pore/envelope | 4.59 | 15 |
| 14 | ATP biosynthetic process | 4.49 | 16 |
| 15 | Protein‐tyrosine phosphatase, dual specificity | 4.31 | 5 |
| 16 | COPI vesicle | 3.87 | 14 |
| 17 | Mitochondrial membrane | 3.61 | 10 |
| 18 | Ubl conjugation pathway | 3.35 | 16 |
| 19 | Transcription regulation | 2.91 | 46 |
| 20 | Actin‐binding | 2.81 | 6 |
| 21 | Transcription factor activity | 2.68 | 21 |
| 22 | Intracellular protein transport | 2.51 | 5 |
| 23 | Nucleosome | 2.38 | 4 |
| 24 | Tetratricopeptide repeat | 2.2 | 4 |
| 25 | Regulation of Ras GTPase activity | 1.7 | 6 |
| 26 | Golgi apparatus | 1.66 | 10 |
| 27 | Leucine‐rich repeat | 1.66 | 4 |
| 28 | WD40 repeat | 1.35 | 17 |
#
Ranked according to enrichment score.
*
Enrichment score indicates the degree to which genes associated with a particular function/pathway are over‐represented in this list relative to their representation in the entire genome.