Figure 7.

(A) Effect of hydralazine on hydrogen peroxide and lipid hydroperoxide stability. Hydrogen peroxide and the lipid hydroperoxide 15-HpETE were incubated in the absence or presence of two different concentrations of hydralazine. After 2 h, residual peroxide levels were determined with the FOX assay as described in Materials and methods. (B) Effect of hydralazine on the stability of pyrogallol-generated superoxide. Pyrogallol (0.2 mM) was incubated in the absence or presence of two different concentrations of hydralazine and the rate of auto-oxidation was determined as described in Materials and methods. Values are expressed as percentage of control (i.e. without hydralazine) and represent the mean ± SEM of three experiments. Asterisks denote values that are significantly different (p < 0.05) from controls.