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. 2011 Sep 19;194(6):825–839. doi: 10.1083/jcb.201101148

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© 2011 Fessing et al.

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Figure 2. — p63 controls the expression of Satb1 in epidermal progenitor cells. The skin of p63-deficient and WT embryos was processed for immunofluorescent analyses as well as for modulation of gene expression in organ culture experiments with p63 siRNA. (A) Double immunofluorescence showing coexpression of p63 and Satb1 in the nuclei of basal epidermal cells in E16.5 WT mice. (B and C) Immunostaining for Satb1 (B) and K18 (C) in the E16.5 skin of WT and p63^−/− mice. Marked decrease of Satb1 expression in the epidermis (EP) of p63^−/− mice is magnified in the dashed boxes. (D) Immunostaining for p63, Satb1, and Loricrin in the E13.5 skin samples of heterozygous p63 knockout (+/−) mice cultured in the presence of p63 siRNA or control siRNA for 48 h. In epidermis, the expression of p63, Satb1, and Loricrin proteins in the p63 siRNA–treated samples was decreased compared with the controls. (B and D) The epidermal–dermal junction is shown by dotted lines. Bars, 25 µm.