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. Author manuscript; available in PMC: 2012 Oct 19.
Published in final edited form as: Bioconjug Chem. 2011 Sep 30;22(10):2136–2142. doi: 10.1021/bc200411n

Scheme 2.

Scheme 2

PEGylation of 3′ amino-modified DNA A. PEGylation reaction of 3′ amino-modified DNA with N-hydroxysuccinimide PEG. B. PEGylation and decaging of DsRed targeting antisense DNA with the PhotoPEG reagent. C. Representative PAGE analysis of purified, PEGylated DNA. Lane 1: non-modified antisense agent (AA). Lane 2: 5 kDa PEGylated antisense agent (AA-5 kDa PEG). Lane 3: 20 kDa photocleavable PEGylated antisense agent (AA-5K PhotoPEG).