TABLE 1.

Values of model parameters used in the ABM and CMM to simulate the bio-chemo-mechanical response of a mouse abdominal aorta to altered blood pressure. These values were inferred from the literature and deemed either to be reliable or to be reasonable based on prior parameter sensitivity studies; hence, they were fixed and not optimized in the minimization procedure to increase congruency. For detailed information on the constitutive relations or rules in which the parameters occur, please see the original papers^15,18.

Prescribed (Fixed) Parameters
CMM	References
Prestretches and Elastic Parameters
$G_h^e=1.4$, $G_h^c=1.08$, $G_h^m=1.3$	[12]
ce = 58.8 KPa, $c_1^c=560.4kPa$, $c_1^m=12.7kPa$, $c_2^c=22$, $c_2^m=3.5$
Muscle Activation and Shear-Constrictor Ratio
TM = 150 KPa, λM = 1.6, λ0 = 0.83	[36]
CB = 0.68	[18]
Initial Mass Fractions and Half-lives
ϕc(0) = 0.44, ϕe(0) = 0.28 ϕm(0) = 0.28	[37,38]
$K_h^m=1∕80{\mathit{day}}^{-1}$,$K_h^c=1∕80{\mathit{day}}^{-1}$	[2,39]
ABM
Growth Factors
δPDGF = 0.15, αPDGF = 0.84, ΚPDGF = 0.42, nPDGF = 1.24	[40,41]
MPDGF = 0.78 pg cell−1 6hr−1
Vasoactive Factors
δET−1 = 0.60, αET−1 = 0.40, κET−1 = 3.63, nET−1 = 1.68	[42,43]
MET−1 = 0.01 pg cell−1 6hr−1
Removal Factors
δMMP−2 = 0.03, αMMP−2 = 0.52, κMMP−2 = 2.0E – 06, nMMP−2 = 2.84	[32,33]
MMMP−2 = 1 pg cell−1 6hr−1, DMMP−2 = 99, AMMP−2 = 0.001
δMMP−9 = 0.04, αMMP−9 = 0.44, κMMP−9 = 4.0E – 06, nMMP−9 = 2.88	[32,44]
MMMP−9 = 0.002 pg cell−1 6hr−1, DMMP−9 = 87, AMMP−9 = 0.003, DMMP−1 = 80.6