Symbol (units)	Classification	Definition
$K_{{\sigma }_{\theta }}^c$	CMM: Bounded	Gain parameter governing circumferential-stress mediated rate of production of collagen. See Eq. (1)
$K_{{\sigma }_{\theta }}^m$	CMM: Bounded	Gain parameter governing circumferential-stress mediated rate of production of smooth muscle. See Eq. (1)
$K_{{\tau }_w}^c$	CMM: Bounded	Gain parameter governing shear-stress mediated rate of production of collagen. See Eq. (1)
$K_{{\tau }_w}^m$	CMM: Bounded	Gain parameter governing shear-stress mediated rate of production of smooth muscle. See Eq. (1)
MMP-10 (pg)	ABM: Bounded	Baseline mass of MMP-1
MMP-1%A (%)	ABM: Bounded	Percent of MMP-1 that is active
C0 (pg)	ABM: Bounded	Baseline mass of collagen
CTGF	ABM: Bounded	Rate parameter governing TBFb mediated rate of production of collagen (pg of collagen per pg of TGFb)
Mp	ABM: Bounded	Rate parameter governing PDGF mediated SMC proliferation rate (pg of SMC per pg of PDGF)
M0 (pg)	ABM: Bounded	Baseline SMC proliferation rate (pg)
Ma1	ABM: Bounded	Apoptosis chance for SMC (1)
Ma2	ABM: Bounded	Baseline apoptosis chance for SMC (2)
PDGFσθ(pg/kPa)	ABM: Bounded	Rate parameter governing hoop stress mediated rate of production of PDGF (pg of PDGF per kPa of stress)
PDGF0 (pg)	ABM: Bounded	Baseline mass of PDGF
TGFβσθ (pg)	ABM: Bounded	Rate parameter governing hoop stress mediated rate of production of TGFb (pg of TGFb per kPa of stress)
TGFβ0 (pg)	ABM: Bounded	Baseline mass of TGFb
$G_h^e$	CMM: Observed	Homeostatic stretch when elastin is deposited
$G_h^c$	CMM: Observed	Homeostatic stretch when collagen is deposited
$G_h^m$	CMM: Observed	Homeostatic stretch when SMC is deposited
Ce (kPa)	CMM: Calculated	Neo-Hookean material parameter for the stored energy of elastin
$c_1^c\left(kPa\right)$	CMM: Calculated	Fung-type exponential material parameter for the stored energy of collagen (1)
$c_1^m\left(kPa\right)$	CMM: Calculated	Fung-type exponential material parameter for the stored energy of SMC (1)
$c_2^c$	CMM: Observed	Fung-type exponential material parameter for the stored energy of collagen (2)
$c_2^m$	CMM: Observed	Fung-type exponential material parameter for the stored energy of SMC (2)
Tm(kPa)	CMM: Observed	Maximum stress generated by SMC
λM	CMM: Observed	Circumferential stretch where active stress is maximum
λ0	CMM: Observed	Circumferential stretch where active stress is zero
CB	CMM: Observed	Material parameter for the ratio of constrictor concentration to dilator concentration
CS	CMM: Observed	Scaling parameter for shear stress induced change in constrictor concentration scaling factor
ϕc(0)	CMM: Observed	Initial mass fraction of collagen in the arterial wall
ϕe(0)	CMM: Observed	Initial mass fraction of elastin in the arterial wall
ϕm(0)	CMM: Observed	Initial mass fraction of SMC in the arterial wall
$K_h^m\left({\mathit{days}}^{-1}\right)$	CMM: Observed	Half-life of SMC
$K_h^c\left({\mathit{days}}^{-1}\right)$	CMM: Observed	Half-life of collagen
NO0 (pg)	ABM: Observed	Baseline mass of NO
NOτw	ABM: Observed	Rate parameter governing shear stress mediated rate of production of NO (pg of NO per kPa of stress)
δPDGF (pg) αPDGF κPDGF(kPa−1) nPDGF MPDGF	ABM: Observed	Parameters of the sigmoid function: PDGF = M (δ + α(1 – e−kxn)) Maximum rate of PDGF production
δET–1 (pg) αET–1 κET–1 (kPa−1 nET–1 MET–1	ABM: Observed	Parameters of the sigmoid function: ET1 = M (δ + α(1 – e−kxn)) Maximum rate of ET-1 production
δMMP–2 (pg) αMMP–2 κMMP–2 (kPa−1) nMMP–2 MMMP–2 AMMP–2 (%)	ABM: Observed	Parameters of the sigmoid function: MMP2 = A (M (δ +α(1 – e−kxn))) Maximum rate of MMP-2 production Percent of MMP-2 Active
DMMP–2	ABM: Observed	Degradation rate of MMP-2
δMMP–9 (pg) αMMP–9 κMMP–9 (KPa−1 nMMP–9 MMMP–9 AMMP–9 (%)	ABM: Observed	Parameters of the sigmoid function: MMP9 = A (M (δ +α(1 – e−kxn))) Maximum rate of MMP-9 production Percent of MMP-9 Active
DMMP–9	ABM: Observed	Degradation rate of MMP-9
DMMP–1	ABM: Observed	Degradation rate of MMP-1

Note: Parameters within the ABM or CMM are classified as observed, bounded, or calculated. Observed parameters were either cited elsewhere or obtained via direct measurements or fits to experimental data. Bounded parameters are less well known, but are expected to fall within specified range. Lastly, calculated parameters include those that are needed to satisfy equilibrium under homeostatic conditions.