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. 2011 Sep 9;286(44):38027–38034. doi: 10.1074/jbc.M111.275503

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — MondoA-activated TXNIP expression requires hexokinase activity. A, HA1ER cells transfected with MondoA-V5 and FLAG-Mlx were glucose (Gluc)-starved overnight and then treated with the indicated hexoses (20 mm; 3h) ± 3BrPA (20 μm). Percentage of cells displaying nuclear immunolocalization of MondoA-V5 is shown. B, activity of TXNIP luciferase reporter was determined following hexose treatment of HA1ER cells expressing MondoA RNAi or control RNAi ± 3-BrPA. C, levels of the indicated hexoses in MEFs were determined by mass spectrometry. Error bars, S.D.