FIGURE 11.

Summary of sequence-specific interactions that have been observed between classical zinc fingers and DNA (adapted from Wolfe et al. (46)). Rectangles represent nucleotides in dsDNA. The four nucleotides that have been shown most frequently to be contacted by residues in classical zinc fingers are shaded gray. Rounded rectangles show the position of residues in the recognition helix that have been shown to contact the indicated bases, and an example of a zinc finger that displays each type of interaction is given (Zif268–1 indicates finger 1 of Zif268) (18, 19, 45, 60).