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The α1(K378E) mutation decreased chord conductance. A, shown are single channel currents from outside-out patches containing WT and α1(K378E) receptors at membrane holding potentials of +20 and +40 mV. Open and closed levels are denoted by O and C, respectively. B, IV relationship of WT (solid) and α1(K378E) (dashed) single channel currents.
