TABLE 1.
Th1, Th2, and proinflammatory cytokines in lung tissue from control and OVA-challenged WT and Mgat5−/− mice
ND indicates not detectable (n = 4–6 per group).
Cytokine | WT mice (mean ± S.E.) |
Mgat5−/− mice (mean ± S.E.) |
||
---|---|---|---|---|
Control | OVA | Control | OVA | |
pg/mg protein | pg/mg protein | |||
IL-4 | 4.97 ± 0.21 | 9.27 ± 1.04a | 4.39 ± 0.12 | 6.64 ± 0.33a,b |
IL-5 | 4.18 ± 0.3 | 14.33 ± 1.42a | 3.86 ± 0.19 | 7.03 ± 0.35a,b |
IL-13 | 3.81 ± 0.87 | 49.41 ± 9.72a | 3.85 ± 0.36 | 14.78 ± 2.65a,b |
IFNγ | 0.44 ± 0.16 | 12.29 ± 2.26a | 0.01 ± 0.01 | 9.08 ± 3.16a |
IL-2 | 9.0 ± 0.99 | 7.02 ± 0.98 | 10.48 ± 1.16 | 7.42 ± 0.48 |
IL-17A | ND | 60.63 ± 21.58a | ND | 41.89 ± 2.94a |
TNFα | 15.73 ± 1.45 | 207.38 ± 35.39a | 24.81 ± 7.07 | 144.75 ± 17.46a |
a p < 0.05 control versus OVA-challenged groups for WT and Mgat5−/− mice.
b p < 0.05 OVA-challenged Mgat5−/− mice versus allergen-challenged WT mice.