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. 2011 Sep 7;286(44):38592–38601. doi: 10.1074/jbc.M111.252171

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Neuronal differentiation is impaired in aged NPCs. Young adult NPCs (A and B) and aged adult NPCs (C and D) were subjected to optimized differentiation protocols in vitro. Young adult NPCs (A) differentiated into significantly more MAP2⁺ neurons than aged adult NPCs (C), when plated under permissive conditions (E, p < 0.05; error bars, S.E.). Young NPCs (B) differentiated into significantly fewer glial fibrillary acidic protein-positive (GFAP⁺) astrocytes than aged NPCs (D), when plated in serum (E, p < 0.05). Scale bars, 10 μm.