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. 2011 Sep 7;286(44):38592–38601. doi: 10.1074/jbc.M111.252171

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Aged NPCs have fewer mitochondria and are resistant to rotenone toxicity. A and B, numbers of JC1⁺ mitochondria (red) were quantified in young adult (A) and aged adult (B) NPCs. Scale bars, 5 μm. C, a significant decrease in JC1⁺ mitochondria/cell was observed in aged NPCs (p < 0.0001; error bars, S.E.). D, a significant decrease in citrate synthase activity was observed in aged NPCs (p < 0.01). E and F, cell viability (E) and cell number (F) significantly decreased in both young and aged NPCs upon exposure to 50 nm and 100 nm of rotenone; viability of young NPCs also significantly decreased after exposure to 10 nm rotenone (p < 0.01), whereas aged NPCs were unaffected (p > 0.05).