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. 2011 Sep 7;286(44):38592–38601. doi: 10.1074/jbc.M111.252171

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Aged NPCs contain fewer Complex V⁺ mitochondria in vivo. A and B, Nestin-labeled NPCs (red) with DAPI-labeled nuclei (blue) within the young adult (A) and aged adult (B) SVZ contain perinuclear Complex V⁺ mitochondria (green). C and D, BrdU-labeled NPCs (red) with DAPI-labeled nuclei (blue) within the young (C) and aged (D) SVZ contain perinuclear VDAC⁺ mitochondria (green). Scale bars, 1 μm. A single representative optical plane representing mitochondria is overlapped with a nearby optical plane showing nuclear staining in each photomicrograph. Complex V⁺ mitochondria were counted within circled regions of interest in the perinuclear region of Nestin⁺ cells (A and B); VDAC⁺ mitochondria were counted within the perinuclear region of BrdU⁺ cells. E and F, aged NPCs contained, on average, 24% fewer Complex V⁺ mitochondria (E, p < 0.05) and 26% fewer VDAC⁺ mitochondria (F, p < 0.05) per cell compared with young NPCs.