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Schematic of the proposed mechanism of activation and turnover of BlaR1. The process of antibiotic recognition on the cell surface leads to activation of the zinc protease in the cytoplasmic domain. The protease activity degrades BlaI, resulting in derepression of the antibiotic resistance genes, including that for BlaR1 itself. BlaR1 experiences fragmentation at two discrete sites, including one that sheds the sensor domain (BlaRS) from the membrane.
