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. 2011 Aug 10;286(44):37976–37989. doi: 10.1074/jbc.M111.263673

FIGURE 8.

FIGURE 8.

Effects of nAChR α6 subunit N-terminal domain amino acid substitutions on functional responsiveness of α6β2β3-nAChR to nicotinic ligands. A, mean (±S.E.) peak inward current responses upon exposure (10 s) to 100 μm nicotine (10 s exposure; ordinate) from oocytes (n = 4) voltage-clamped at −70 mV and heterologously expressing the indicated nAChR subunits. B, mean (±S.E.) apparent peak outward current responses upon exposure (10 s) to 1000 μm mecamylamine (10 s exposure; ordinate) from oocytes (n = 4) voltage-clamped at −70 mV and heterologously expressing the indicated nAChR subunits. *, p < 0.05; **, p < 0.01; ***, p < 0.001. hα6(N143D) subunits are present in hα6hβ2*-nAChR that have the largest amplitude responses to nicotine and the largest amplitude for mecamylamine-sensitive spontaneous openings, whether in the presence of wild-type or mutant hβ3 subunits.