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Hydrolytic activity measurements. Normalized hydrolytic activity of the SERCA pump in the presence of NF1442 (filled circles), NF1610 (empty circles), and NF1058 (empty triangles). Solid and dashed lines represent best fittings to the experimental data obtained for NF1442 and NF1058, respectively. The kinetic constants are IC50 = 1.3 ± 0.2 μm, n = 1.1 ± 0.2 (solid line) and IC50 = 8 ± 2 μm, n = 0.9 ± 0.2 (dashed line). Error bars are the S.D.
