FIGURE 7.

Group-specific amino acid residues in S46.001-subfamily members. A, shown is the phylogenetic tree of the S46.001 subfamily of S46/DPP7 family. Numbers in parentheses indicate number of members (supplemental Table S3). B, 20 amino acids of PeDPP11 completely conserved in Group-3 members and simultaneously not present in any member of Group 4 and vice versa were compared among Group 1–5 members. Amino acids unique to each group are shown in capital letters, whereas others are shown together in each box with small letters. Note that the amino acid at position 670 is completely conserved among all members of Groups 1, 3, and 5 as Gly and Groups 2 and 4 as Arg.